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pentobarbital will lessen the extent or influence of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Powerful or moderate CYP3A4 inducers drastically cut down guanfacine plasma concentrations and elimination 50 %-life.pentobarbital will lessen the extent or effect of theophylline by affecting